Mechanism Of Tolerance Breakdown With Functional Defect

Match the mechanism of tolerance breakdown with the functional defect that could directly cause that tolerance breakdown to increase risk of autoimmunity. reversal of anergy in T cells ?[ ??????? ] FoxP3 gene defect AIRE gene defect high levels of IL-2 CTLA-4 gene defect Unregulated T cell proliferation Loss of Treg function [ ??????? ] Significantly reduced negative selection [ ??????? ] <